Duoride-T 0.5mg/0.4mg Capsules 30s

Duoride-T 0.5mg/0.4mg Capsules 30s is a prescription urology medicine containing dutasteride 0.5mg and tamsulosin hydrochloride 0.4mg in each capsule.

It is used in adult men with moderate-to-severe symptoms of benign prostatic hyperplasia, commonly abbreviated as BPH. BPH is a non-cancerous enlargement of the prostate that may affect urinary flow and cause lower urinary tract symptoms.

Duoride-T combines two medicines with complementary actions. Dutasteride helps reduce prostate enlargement over time, while tamsulosin relaxes muscles around the prostate and bladder neck to support improved urinary flow.

Duoride-T 0.5mg/0.4mg Product Information

What Is Duoride-T Used For?

Duoride-T is used for the treatment of moderate-to-severe symptoms of benign prostatic hyperplasia in adult men with an enlarged prostate.

BPH may cause urinary symptoms including:

• Difficulty starting urination
• A weak or interrupted urine stream
• Needing to strain during urination
• Frequent urination
• Urgent need to urinate
• Waking frequently at night to urinate
• A feeling that the bladder has not emptied completely

Combination treatment can help improve urinary symptoms and urinary flow. By reducing prostate enlargement over time, dutasteride-containing treatment may also help reduce the risk of acute urinary retention and the need for BPH-related surgery in appropriately selected patients.

Duoride-T is not approved for the prevention of prostate cancer. Other prostate, bladder and urinary conditions can cause similar symptoms and should be evaluated before treatment begins.

How Duoride-T Works

Dutasteride

Dutasteride is a 5-alpha-reductase inhibitor. It blocks type 1 and type 2 forms of the enzyme that convert testosterone into dihydrotestosterone, commonly abbreviated as DHT.

DHT contributes to prostate enlargement. Reducing DHT levels can gradually reduce prostate volume and help slow the progression of BPH.

Tamsulosin

Tamsulosin is an alpha-1 adrenergic receptor blocker. It relaxes smooth muscle around the prostate and bladder neck, helping urine pass more easily through the urinary tract.

Tamsulosin may improve urinary symptoms earlier, while the prostate-reducing effects of dutasteride generally develop more gradually.

How to Take Duoride-T

• Take Duoride-T exactly as prescribed by the treating doctor.
• The usual reference dosing for this combination is one capsule once daily.
• Take the capsule approximately 30 minutes after the same meal each day.
• Swallow the capsule whole with water.
• Do not chew, crush, open or dissolve the capsule.
• Do not take the capsule on an empty stomach unless specifically instructed.
• Do not take two capsules to compensate for a missed dose.
• If treatment has been interrupted for several days, consult the doctor before restarting.

Opening or chewing the capsule may expose the mouth and throat to contents that can cause irritation. Follow the approved Malaysian package insert and the instructions printed on the dispensing label.

How Long Does Duoride-T Take to Work?

The tamsulosin component may improve certain urinary symptoms relatively early. The full effect of dutasteride on prostate size and BPH progression develops more gradually.

Some patients may require several months of treatment before the overall response can be properly assessed. Continue taking the medicine for the prescribed duration even when improvement is not immediate.

Medical Assessment and PSA Monitoring

Symptoms associated with BPH can also occur with prostate cancer, bladder conditions, urinary infection and other urological disorders. Appropriate examination should be performed before treatment and periodically afterward.

Dutasteride can reduce measured prostate-specific antigen, commonly known as PSA, by approximately 50% after several months of treatment. The treating doctor must consider this effect when interpreting PSA results.

Any confirmed rise from the lowest PSA level achieved during treatment should be assessed, even when the value remains within the usual reference range for untreated men.

Important Safety Information

• Duoride-T is intended for adult men and should not be used by women or children.
• The medicine may cause dizziness, light-headedness or fainting, particularly when standing up.
• Rise slowly after sitting or lying down.
• Avoid driving, operating machinery or hazardous activities until the individual response is known.
• Do not combine Duoride-T with another alpha-blocker unless specifically directed.
• Tell the doctor about all blood-pressure, erectile-dysfunction and prostate medicines being used.
• Inform an eye surgeon before cataract or glaucoma surgery that Duoride-T is being taken or has been taken previously.
• Do not donate blood during treatment or for at least six months after the final dose.
• Attend scheduled prostate examinations, PSA tests and treatment reviews.

Who Should Not Take Duoride-T?

Duoride-T may be contraindicated or unsuitable for patients who:

• Are allergic to dutasteride, tamsulosin, another 5-alpha-reductase inhibitor or an ingredient in the capsule
• Have a history of significant postural or orthostatic hypotension
• Have severe liver impairment
• Have severe renal impairment
• Are already taking another alpha-1 adrenergic blocker
• Are women or children

The treating doctor should assess kidney function, liver function, blood pressure, prostate health and the complete medication list before prescribing the product.

Dizziness, Low Blood Pressure and Fainting

Tamsulosin may cause a sudden reduction in blood pressure when standing, particularly when treatment is first started or restarted.

Symptoms may include:

• Dizziness
• Light-headedness
• Weakness
• Blurred vision
• Fainting

Sit or lie down if symptoms develop. Seek medical advice when symptoms are severe, persistent or result in a fall or injury.

Pregnancy and Handling Precautions

Women who are pregnant or may become pregnant must not handle leaking or damaged Duoride-T capsules. Dutasteride can be absorbed through the skin and may affect the development of a male fetus.

If contact with a leaking capsule occurs, wash the affected area immediately with soap and water and obtain professional advice.

Intact capsules should remain in their original packaging and be handled according to the instructions provided by the pharmacist.

Cataract and Glaucoma Surgery

Tamsulosin has been associated with intraoperative floppy iris syndrome during cataract and glaucoma surgery.

Patients should tell their ophthalmologist or eye surgeon that they currently take or have previously taken Duoride-T. This information remains important even when the medicine was stopped before the planned procedure.

Sexual and Reproductive Effects

Possible sexual effects associated with dutasteride and tamsulosin include:

• Reduced sexual desire
• Difficulty obtaining or maintaining an erection
• Reduced semen volume
• Changes in ejaculation
• Retrograde ejaculation or ejaculation failure

Some sexual effects have been reported to continue after treatment is stopped. Dutasteride may also reduce sperm count, semen volume and sperm movement. The overall effect on male fertility is uncertain.

Patients concerned about fertility or persistent sexual symptoms should discuss these issues with their doctor.

Mood Changes

Depressed mood and depression have been reported in patients using dutasteride. Current European safety recommendations advise patients taking dutasteride to seek medical advice if they experience depressed mood, depression or suicidal thoughts.

Any significant change in mood or behaviour should be treated seriously and assessed promptly by a healthcare professional.

Possible Side Effects

Not everyone experiences side effects. Possible effects associated with dutasteride and tamsulosin include:

• Dizziness or light-headedness
• Ejaculation disorders
• Difficulty obtaining or maintaining an erection
• Reduced sexual desire
• Breast enlargement or tenderness
• Runny or blocked nose
• Headache
• Weakness or tiredness
• Digestive discomfort
• Depressed mood

Report persistent, worsening or troublesome side effects to a doctor or pharmacist.

Serious Symptoms Requiring Medical Attention

Seek prompt or urgent medical attention if any of the following occurs:

• Swelling of the face, lips, tongue or throat
• Difficulty breathing or swallowing
• Fainting or a severe fall in blood pressure
• A severe, blistering or peeling skin reaction
• A painful erection lasting several hours
• A breast lump, nipple discharge or significant breast change
• Severe mood changes or suicidal thoughts
• Sudden inability to pass urine
• Another severe or unexpected reaction

Medicine Interactions

Tell the doctor and pharmacist about all prescription medicines, non-prescription products, traditional medicines and supplements being used.

Medicines requiring particular consideration include:

• Other alpha-blockers: combined use may cause excessive blood-pressure reduction.
• Strong CYP3A4 inhibitors: medicines such as ketoconazole may substantially increase tamsulosin exposure.
• Other CYP3A4 or CYP2D6 inhibitors: medicines including erythromycin, paroxetine and terbinafine may require clinical review.
• PDE-5 inhibitors: medicines such as sildenafil or tadalafil may increase the risk of symptomatic low blood pressure.
• Blood-pressure medicines: combined effects may increase dizziness or hypotension.
• Warfarin: concurrent treatment requires caution and professional monitoring.
• Cimetidine: this may affect tamsulosin exposure.
• Other medicines containing dutasteride, finasteride or tamsulosin: duplication should be avoided unless specifically directed.

Do not start, stop or change another medicine without consulting the treating doctor or pharmacist.

Blood Donation

Men taking Duoride-T should not donate blood during treatment or for at least six months after the final dose.

This precaution helps prevent pregnant recipients from being exposed to dutasteride through donated blood.

Storage Instructions

• Store according to the conditions printed on the carton and approved package insert.
• Keep the capsules in their original blister packaging until required.
• Protect from excessive heat and moisture.
• Do not use capsules that are damaged, leaking, deformed or discoloured.
• Keep out of reach of children.
• Do not use after the expiry date printed on the supplied packaging.
• Product packaging, batch number and expiry date may vary between supplied batches.

Frequently Asked Questions

What are the active ingredients in Duoride-T?

Each Duoride-T capsule contains dutasteride 0.5mg and tamsulosin hydrochloride 0.4mg.

What is Duoride-T used for?

Duoride-T is used to treat moderate-to-severe symptoms of benign prostatic hyperplasia in adult men with an enlarged prostate.

What is benign prostatic hyperplasia?

Benign prostatic hyperplasia is a non-cancerous enlargement of the prostate. It can restrict urinary flow and cause symptoms such as frequent urination, a weak stream and difficulty emptying the bladder.

How does Duoride-T improve BPH symptoms?

Dutasteride gradually reduces prostate enlargement by lowering DHT, while tamsulosin relaxes muscles around the prostate and bladder neck to improve urinary flow.

Is Duoride-T a prescription medicine in Malaysia?

Yes. Duoride-T is registered in Malaysia as a Prescription-Full medicine under registration number MAL22126056ACZ.

Who manufactures Duoride-T?

Duoride-T is registered to Novugen Pharma Sdn. Bhd. and manufactured by SAG Manufacturing S.L.U., Spain.

How many capsules are supplied in one pack?

The P-Hub listing contains 30 capsules, supplied as five blister strips of six capsules.

When should Duoride-T be taken?

The reference dosing for this combination is one capsule approximately 30 minutes after the same meal each day. Patients must follow their individual prescription and approved package insert.

Can Duoride-T be taken on an empty stomach?

The capsule should generally be taken after the same meal each day. Taking it on an empty stomach may increase the risk of cardiovascular adverse effects such as postural low blood pressure.

Can the capsule be opened or chewed?

No. The capsule should be swallowed whole. Opening or chewing it may expose the mouth and throat to irritating capsule contents.

Does Duoride-T work immediately?

Tamsulosin may improve some urinary symptoms relatively early, while the prostate-reducing effects of dutasteride usually require longer treatment. Several months may be required to assess the overall response.

Does Duoride-T affect PSA test results?

Yes. Dutasteride can lower measured PSA levels by approximately 50% after several months. The doctor should account for this effect when interpreting prostate screening results.

Can women use Duoride-T?

No. Duoride-T is intended for adult men. Women who are pregnant or may become pregnant should not handle leaking or damaged capsules.

Can Duoride-T affect sexual function?

Possible effects include reduced libido, erectile difficulty, reduced semen volume and ejaculation disorders. Patients should consult their doctor if these effects are persistent or concerning.

Can Duoride-T cause dizziness?

Yes. Tamsulosin may cause dizziness or a sudden reduction in blood pressure when standing. Patients should rise slowly and avoid hazardous activities until they know how the medicine affects them.

Can a patient donate blood while taking Duoride-T?

No. Blood donation should be avoided during treatment and for at least six months after the final dose.

Can pharmacies request Duoride-T through P-Hub?

Duoride-T 0.5mg/0.4mg Capsules 30s is listed in the P-Hub B2B catalogue for approved pharmacy members. Quotation, ordering eligibility and supply are subject to P-Hub membership requirements, prescription medicine controls and current stock availability.

Prescription Medicine Notice

Duoride-T 0.5mg/0.4mg is a prescription medicine. It should only be supplied, dispensed and used according to applicable Malaysian requirements and the directions of a registered doctor or pharmacist.

The information on this page is provided for pharmacy catalogue and professional product-reference purposes. It does not replace an individual medical assessment, prescription, approved Malaysian package insert or advice from a qualified healthcare professional.

Product appearance, packaging, batch number, availability and expiry date may vary. Verify all information on the physical product packaging and approved insert before dispensing or use.

Product Information Sources

• Novugen Pharma – Duoride-T Product Information
  
• National Pharmaceutical Regulatory Agency Malaysia – Duoride-T Registration Record
  
• Singapore National Drug Formulary – Dutasteride and Tamsulosin Product Information
  
• DailyMed – Dutasteride and Tamsulosin Prescribing Information
  
• European Medicines Agency – Dutasteride Mood-Change Safety Update
  

Product information last reviewed: 11 July 2026.