Co-Diovan 160mg/25mg Tablets 28s

Co-Diovan 160mg/25mg Tablets 28s is a prescription combination medicine containing valsartan 160mg and hydrochlorothiazide 25mg in each film-coated tablet.

It is used to treat hypertension, commonly known as high blood pressure, in selected adults whose blood pressure is not adequately controlled with a single antihypertensive medicine.

Co-Diovan combines an angiotensin II receptor blocker with a thiazide diuretic. The 25mg hydrochlorothiazide strength provides a higher diuretic component than the 160mg/12.5mg formulation and should only be selected according to the patient’s clinical requirements, blood pressure response and medical assessment.

Co-Diovan 160mg/25mg Product Information

What Is Co-Diovan 160mg/25mg Used For?

Co-Diovan 160mg/25mg is used for the treatment of hypertension in adults aged 18 years and above. It may be prescribed when blood pressure is not adequately controlled by antihypertensive monotherapy.

The 160mg/25mg formulation contains a higher hydrochlorothiazide strength than Co-Diovan 160mg/12.5mg. It may be considered when the treating doctor determines that a stronger diuretic component is clinically necessary.

Co-Diovan should not be selected or substituted without medical assessment. The prescribing doctor should consider the patient’s blood pressure, kidney function, liver function, electrolyte levels, hydration status, medical history and concurrent medicines.

How Co-Diovan Works

Valsartan

Valsartan is an angiotensin II receptor blocker, commonly abbreviated as an ARB. Angiotensin II is a natural substance that causes blood vessels to tighten.

Valsartan blocks the action of angiotensin II at its receptors. This helps blood vessels relax and supports a reduction in blood pressure.

Hydrochlorothiazide

Hydrochlorothiazide is a thiazide diuretic, sometimes described as a water tablet. It increases the removal of sodium and water through the urine, helping reduce fluid volume and lower blood pressure.

The two active ingredients work through complementary mechanisms to provide additional blood-pressure control compared with either component used alone.

How to Take Co-Diovan 160mg/25mg

• Take Co-Diovan exactly as prescribed by the treating doctor.
• The approved product information generally recommends one Co-Diovan tablet daily when the selected strength is clinically appropriate.
• Swallow the tablet with water.
• The medicine may be taken with or without food.
• Take the tablet at approximately the same time each day unless instructed otherwise.
• Do not divide the tablet to obtain an equal half-dose.
• Do not increase, reduce or stop treatment without medical advice.
• Do not take a double dose to replace a missed dose.

The full antihypertensive effect may take approximately two to four weeks to develop. Continue treatment according to the prescribed schedule even when there are no noticeable symptoms.

Monitoring During Treatment

A doctor may monitor the following before and during treatment:

• Blood pressure
• Kidney function
• Blood potassium and sodium levels
• Magnesium and calcium levels
• Blood uric acid
• Blood glucose in patients with diabetes or increased diabetes risk
• Signs of dehydration or excessive blood-pressure reduction

Monitoring is particularly important because the 25mg hydrochlorothiazide component can produce a greater diuretic effect and may increase the likelihood of fluid or electrolyte disturbances in susceptible patients.

Important Safety Information

• Co-Diovan is a prescription medicine and should not be shared with another person.
• It must not be used during pregnancy.
• Inform the doctor immediately if pregnancy occurs or is suspected during treatment.
• Tell the prescriber about kidney disease, liver disease, gout, diabetes, lupus or electrolyte abnormalities.
• Dehydration caused by vomiting, diarrhoea, heavy sweating or inadequate fluid intake may increase the risk of low blood pressure or kidney problems.
• Rise slowly from sitting or lying positions if dizziness occurs.
• Do not drive or operate machinery if dizziness, faintness or reduced alertness is present.
• Do not use potassium supplements or potassium-containing salt substitutes unless advised by a healthcare professional.
• Protect the skin from excessive sunlight and report suspicious or changing skin lesions.

Who Should Not Take Co-Diovan?

Co-Diovan may be contraindicated or unsuitable in patients with certain conditions, including:

• Allergy to valsartan, hydrochlorothiazide, sulphonamide-derived medicines or another ingredient in the tablet
• Pregnancy
• Anuria or inability to produce urine
• Severe kidney impairment
• Severe liver impairment
• Biliary cirrhosis or cholestasis
• Persistent low potassium that does not respond to treatment
• Persistent low sodium levels
• High calcium levels
• Symptomatic high uric acid levels

The combined use of Co-Diovan with an aliskiren-containing medicine is contraindicated in certain patients with diabetes or impaired kidney function. The complete medication regimen should be reviewed by the prescribing doctor or pharmacist.

Dehydration and Low Blood Pressure

The hydrochlorothiazide component increases urine production. Patients taking the 25mg strength may be more susceptible to fluid loss, particularly during hot weather, vomiting, diarrhoea, fever, heavy sweating or reduced fluid intake.

Symptoms of dehydration or excessive blood-pressure reduction may include:

• Dizziness or light-headedness
• Fainting
• Unusual weakness
• Dry mouth or excessive thirst
• Reduced urine output
• Confusion

Contact a healthcare professional when significant fluid loss or persistent symptoms occur.

Electrolyte Changes

Co-Diovan may affect blood levels of potassium, sodium, magnesium and calcium. Possible symptoms of an electrolyte imbalance include:

• Muscle weakness or cramps
• Irregular heartbeat or palpitations
• Severe tiredness
• Confusion
• Excessive thirst
• Nausea or vomiting

Laboratory monitoring may be required, especially in patients taking other diuretics, potassium supplements, potassium-sparing medicines or treatments that affect kidney function and electrolyte levels.

Kidney and Liver Considerations

Kidney function should be assessed when clinically appropriate. Co-Diovan is contraindicated in patients with anuria and severe kidney impairment.

Patients with liver or biliary disease should inform their doctor before treatment. The medicine is contraindicated in severe liver impairment, biliary cirrhosis and cholestasis.

Illness, dehydration and concurrent use of certain medicines may increase the risk of impaired kidney function during treatment.

Gout, Diabetes and Metabolic Effects

Hydrochlorothiazide may increase blood uric acid and may trigger or worsen gout in susceptible patients. Patients with a current or previous history of gout should inform the prescribing doctor.

Thiazide diuretics may also affect blood glucose and blood lipid measurements. Patients with diabetes may require closer monitoring or adjustment of their diabetes treatment.

Skin and Sunlight Precautions

Long-term cumulative exposure to hydrochlorothiazide has been associated with an increased risk of certain non-melanoma skin cancers. Patients should use appropriate sun protection and regularly inspect their skin.

Report any new, changing, unusual or non-healing skin lesion to a doctor. Patients with a previous history of skin cancer should discuss ongoing hydrochlorothiazide treatment with their healthcare professional.

Eye Symptoms Requiring Prompt Attention

Hydrochlorothiazide has rarely been associated with sudden short-sightedness and acute angle-closure glaucoma.

Seek prompt medical attention if sudden eye pain or a rapid reduction in vision develops, particularly shortly after starting treatment.

Possible Side Effects

Not everyone experiences side effects. Possible effects associated with valsartan and hydrochlorothiazide include:

• Dizziness or light-headedness
• Low blood pressure
• Dehydration
• Changes in potassium or sodium levels
• Tiredness
• Blurred vision
• Tingling or altered skin sensation
• Cough
• Diarrhoea or digestive discomfort
• Muscle pain or muscle cramps
• Increased blood uric acid
• Changes in kidney-function test results

Contact a doctor or pharmacist if side effects continue, worsen or interfere with normal activities.

Serious Symptoms Requiring Medical Attention

Seek urgent medical attention for symptoms including:

• Swelling of the face, lips, tongue or throat
• Difficulty breathing or swallowing
• Fainting or severe dizziness
• Very low urine output
• Severe weakness, confusion or an irregular heartbeat
• Severe or persistent vomiting or diarrhoea
• Sudden eye pain or sudden vision changes
• A severe, blistering or widespread skin reaction
• Symptoms of a serious allergic reaction

Medicine Interactions

Tell the doctor and pharmacist about all prescription medicines, non-prescription products, traditional medicines and supplements being used. Products requiring particular consideration include:

• Other blood-pressure medicines: combined effects may cause excessive blood-pressure reduction.
• ACE inhibitors, other ARBs or aliskiren: combined renin-angiotensin system blockade may increase the risk of low blood pressure, abnormal potassium levels and impaired kidney function.
• Lithium: lithium concentrations and the risk of toxicity may increase.
• Potassium supplements and potassium-containing salt substitutes: potassium levels may become abnormal.
• Potassium-sparing diuretics: additional monitoring may be necessary.
• Non-steroidal anti-inflammatory medicines: medicines such as ibuprofen or diclofenac may reduce the antihypertensive effect and increase kidney risk in susceptible patients.
• Diabetes medicines: blood-glucose treatment may require review.
• Medicines used for gout: dosage or monitoring requirements may change.
• Digoxin and certain medicines affecting heart rhythm: electrolyte changes may increase cardiac risk.
• Calcium or vitamin D products: blood calcium levels may increase.

Do not start, stop or adjust another medicine without checking with a healthcare professional.

Pregnancy and Breastfeeding

Co-Diovan must not be used during pregnancy. Valsartan acts on the renin-angiotensin system and may cause serious harm to a developing baby.

If pregnancy occurs or is suspected during treatment, contact the prescribing doctor immediately so that Co-Diovan can be discontinued and replaced with a suitable alternative.

Co-Diovan is not advisable during breastfeeding because hydrochlorothiazide passes into human milk and information regarding valsartan in human milk is limited. A doctor should recommend an appropriate alternative treatment.

Use in Children

The safety and effectiveness of Co-Diovan have not been established in patients below 18 years old. It should not be supplied to a child unless specifically prescribed by an appropriate medical specialist.

Storage Instructions

• Store according to the conditions printed on the carton and package insert.
• Keep the tablets in their original blister packaging until required.
• Protect from excessive heat and moisture.
• Keep out of reach of children.
• Do not use tablets that appear damaged or deteriorated.
• Do not use after the expiry date printed on the supplied packaging.
• Product packaging, batch number and expiry date may vary between supplied batches.

Frequently Asked Questions

What are the active ingredients in Co-Diovan 160mg/25mg?

Each film-coated tablet contains valsartan 160mg and hydrochlorothiazide 25mg.

What is Co-Diovan 160mg/25mg used for?

It is used to treat high blood pressure in selected adults whose blood pressure is not adequately controlled with one antihypertensive medicine alone.

What is the difference between Co-Diovan 160mg/25mg and 160mg/12.5mg?

Both strengths contain valsartan 160mg. The difference is the hydrochlorothiazide dose: one contains 25mg and the other contains 12.5mg. The 25mg formulation provides a higher diuretic component and should only be used when prescribed.

Is Co-Diovan an ARB?

Co-Diovan contains valsartan, an angiotensin II receptor blocker. It also contains hydrochlorothiazide, a thiazide diuretic.

Is Co-Diovan a water tablet?

One active ingredient, hydrochlorothiazide, is a diuretic or water tablet that increases the removal of sodium and water through the urine.

Is Co-Diovan 160mg/25mg a prescription medicine?

Yes. Co-Diovan is a prescription medicine and should only be supplied and used under the direction of a registered doctor or pharmacist.

What is the Malaysian registration number?

The Malaysian product registration number for Co-Diovan 160mg/25mg Film-Coated Tablet is MAL09062166ARSZ.

Who manufactures Co-Diovan 160mg/25mg?

The Malaysian NPRA comparator-product record lists Novartis Pharma S.P.A., Italy, as the manufacturer.

How many tablets are supplied in one pack?

The P-Hub listing contains 28 tablets, supplied as two blister strips of 14 tablets.

Can Co-Diovan be taken with food?

Co-Diovan may be taken with or without food and should be swallowed with water. Follow the timing and dosage prescribed by the treating doctor.

Can Co-Diovan be used during pregnancy?

No. Co-Diovan must not be used during pregnancy because valsartan may cause serious harm to a developing baby.

Can a patient stop Co-Diovan when blood pressure improves?

No. High blood pressure frequently causes no noticeable symptoms. Do not stop treatment unless instructed by the prescribing doctor, as blood pressure may rise again.

Can pharmacies request Co-Diovan through P-Hub?

Co-Diovan 160mg/25mg Tablets 28s is listed in the P-Hub B2B catalogue for approved pharmacy members. Quotation, ordering eligibility and supply are subject to P-Hub membership requirements, prescription medicine controls and current stock availability.

Prescription Medicine Notice

Co-Diovan 160mg/25mg is a prescription medicine. It should only be supplied, dispensed and used according to applicable Malaysian requirements and the directions of a registered doctor or pharmacist.

The information on this page is provided for pharmacy catalogue and professional product-reference purposes. It does not replace an individual medical assessment, prescription, approved Malaysian package insert or advice from a qualified healthcare professional.

Product appearance, packaging, batch number, availability and expiry date may vary. Verify all information on the physical product packaging and approved insert before dispensing or use.

Product Information Sources

• Novartis – Co-Diovan Professional Product Information
  
• National Pharmaceutical Regulatory Agency Malaysia – Fixed-Dose Combination Comparator Product Record
  

Product information last reviewed: 11 July 2026.